In my lab we developed Global Biobank Engine to support the visualization and search of genetic association results from UK Biobank. Prof. Euan Ashley called it the Google Maps of the Genome in his book. Global Biobank Engine’s design was inspired by the ExAC browser, which summarized exome sequencing data from over 100k individuals.

Now, there are multiple browsers online including from Finland, the FinnGen browser, which makes available results from their analysis of genetic integrated with medical record data from 500k Finns.

With the release of the ChatGPT Atlas browser we can now automate some of the process of exploring therapeutic hypotheses guided by human genetics, our North Star.

Here, I show you how I used ChatGPT Atlas with AI agent mode to explore these browsers and come up with therapeutic hypotheses. The AI agent does the work itself. It’s an exploration, but interesting nonetheless. I’m impressed with its capabilities. It took 11 minutes while I drank coffee and listened to music. BTW, the make no mistakes prompt is in jest.