{"id":691,"date":"2026-10-26T21:27:52","date_gmt":"2026-10-26T21:27:52","guid":{"rendered":"https:\/\/mrivas.su.domains\/gbe\/?p=691"},"modified":"2026-10-26T21:27:52","modified_gmt":"2026-10-26T21:27:52","slug":"the-molecular-architecture-of-epilepsy","status":"publish","type":"post","link":"https:\/\/mrivas.su.domains\/gbe\/uncategorized\/the-molecular-architecture-of-epilepsy\/","title":{"rendered":"The molecular architecture of epilepsy"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Using the latest Google Argon model we continued our analysis of the epi25.broadinstitute.org exome sequencing data. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We posted our updated dissection of the molecular architecture of epilepsy <a href=\"https:\/\/marivascruz.github.io\/epi25-ultrarare-metaregression\/index.html\">here<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Unified Ultra-Rare Variant Meta-Regression (AF &lt; 0.0001) Integrating Deep-Learning Structural Pathogenicity and<br>Base-Pair Population Constraint Uncovers Chromatin<br>Remodeling, Ion Channel, GATOR1\u2013mTORC1, and<br>Synaptic Architectures Across 20,979 Epilepsy Cases and<br>33,444 Controls. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.dropbox.com\/scl\/fi\/pr03yb93yzrn7grg0d8af\/Molecular-architecture-of-a-neuron.png?rlkey=5c54bif66u7sv7xmalht7tdsv&amp;raw=1\" alt=\"\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Using the latest Google Argon model we continued our analysis of the epi25.broadinstitute.org exome sequencing data. We posted our updated dissection of the molecular architecture of epilepsy here. Unified Ultra-Rare Variant Meta-Regression (AF &lt; 0.0001) Integrating Deep-Learning Structural Pathogenicity andBase-Pair Population Constraint Uncovers ChromatinRemodeling, Ion Channel, GATOR1\u2013mTORC1, andSynaptic Architectures Across 20,979 Epilepsy Cases and33,444 Controls.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-691","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/posts\/691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/comments?post=691"}],"version-history":[{"count":1,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/posts\/691\/revisions"}],"predecessor-version":[{"id":692,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/posts\/691\/revisions\/692"}],"wp:attachment":[{"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/media?parent=691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/categories?post=691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/tags?post=691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}