{"id":510,"date":"2025-10-26T17:37:50","date_gmt":"2025-10-26T17:37:50","guid":{"rendered":"https:\/\/mrivas.su.domains\/gbe\/?p=510"},"modified":"2025-10-28T20:44:16","modified_gmt":"2025-10-28T20:44:16","slug":"phewas-on-a-sphere","status":"publish","type":"post","link":"https:\/\/mrivas.su.domains\/gbe\/uncategorized\/phewas-on-a-sphere\/","title":{"rendered":"PheWAS on a Sphere"},"content":{"rendered":"\n<p>Spherical harmonics are a family of mathematical functions that describe patterns on the surface of a sphere. They are widely used in physics, computer graphics, and <a href=\"https:\/\/www.barnesandnoble.com\/w\/geomathematics-volker-michel\/1140010341?ean=9781108317962&amp;utm_source=chatgpt.com\">geomathematics<\/a>. <\/p>\n\n\n\n<figure class=\"wp-block-video\"><video controls src=\"https:\/\/www.dropbox.com\/scl\/fi\/4cyghsy9gpcbq8l5x027n\/Rotating_Sphere_Hotspot_Identification_Video.mp4?rlkey=btm7a80w1yxxrr09ezpe5n7tt&amp;raw=1\"><\/video><figcaption class=\"wp-element-caption\">Detecting localized genetic effects using spherical harmonics.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Detecting localized genetic effects using spherical harmonics<\/h2>\n\n\n\n<p>Here, we present new approaches to detect localized genetic effects using spherical harmonics. The <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.10.27.684843v1\">write-up is on bioRxiv<\/a> &#8211; we have simulations and apply the framework to FinnGen coding dataset.<\/p>\n\n\n\n<p>If you want to read how spherical harmonics are used for testing against the null of multivariate normality, please see the write-up below.<\/p>\n\n\n\n<div class=\"wp-block-pdf-viewer-block-standard\" style=\"text-align:left\"><div class=\"uploaded-pdf\"><a href=\"https:\/\/mrivas.su.domains\/gbe\/wp-content\/uploads\/2025\/08\/multinormalfinal.pdf\" data-width=\"\" data-height=\"\"><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Spherical harmonics are a family of mathematical functions that describe patterns on the surface of a sphere. They are widely used in physics, computer graphics, and geomathematics. Detecting localized genetic effects using spherical harmonics Here, we present new approaches to detect localized genetic effects using spherical harmonics. The write-up is on bioRxiv &#8211; we have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-510","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/posts\/510","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/comments?post=510"}],"version-history":[{"count":11,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/posts\/510\/revisions"}],"predecessor-version":[{"id":535,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/posts\/510\/revisions\/535"}],"wp:attachment":[{"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/media?parent=510"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/categories?post=510"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mrivas.su.domains\/gbe\/wp-json\/wp\/v2\/tags?post=510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}